The show aired on NBC, April 24, 1955 - January 9, 1958.

As part of the opening for the show, the announcer Fred Collins comes in with "From the far horizons of the unknown come transcribed tales of new dimensions in time and space. These are stories of the future, adventures in which you'll live in a million could-be years on a thousand may-be worlds. The National Broadcasting Company, in coorperation with Street and Smith - publishers of Astounding Science Fiction Magazine - present: X Minus One."

Those appearing on the show were Bill Smith, Donald Buka, Ken Williams, Luis Van Rooten, Matt Crowley, Wendell Holmes, William Griffis, Alexander Scourby, Agnes Young, Joseph Curtin, Joe DeSantis, Ellen Denning, John Thomas, Arthur Anderson, William Keene, William Zuckert, Bill Lipton, Margaret Berlin, Ethel Everett, Edwin Jerome, Peter Capell, Abby Lewis, Edgar Stehli, Ian Martin, Jason Johnson, John Seymore, Lori March, Ed Latimer, Joe DeSantis, Robert Haag, Ross Martin, Santos Ortega, Sydney Smith, Janet Alexander, Ann Pitoriak, Nelson Olmsted, Frank Milano, Michael O'Day, Ken Lynch, Arthur Maitland, Leon Janney, Roger De Koven, Rosemary Prinz, Ted Osborne, John Gibson, Joyce Gordon, Joseph Julian, Owen Jordan, Audrey Blum, Clarke Gordon, Jack Orrison, John Larkin, Reese Taylor, Theo Goetz, Virginia Payne, Mary Patton, Guy Repp, Jack Grimes, Jone Allison, Lynn Cook, Merrill E. Joels, Pat Polen, Arnold Robertson, Edwin Jerome, Bob Hastings, Court Benson, Jack Arthur, Jay Meredith, Milo Boulton, Walter Kinsella, Ivor Francis, Jack Grimes, Jack Hartley, James Dukas, Lyle Sudrow, Robert Dryden, Ross Martin, Sid Raymond, John Thomas, Lawrence Kerr, Ralph Comargo, Stan Early, Karl Weber, Staats Cotsworth, Richard Hamilton, William Malley, Grant Richards, Peggy Lubin, Jack Orrison, Jim Boles, John McGovern, Rita Lloyd, Jan Miner, Anne Seymour, Fredericka Chandler, James Dukas, Grant Richards, Florence Williams, Al Collins, Roy Fant, Mercer McLeod, Guy Sorel, Ginger Jones, Karl Swenson, Les Damon, Theo Goetz, Walter Kinsella, Joey Fallon, Marylou Forster, Pam Thomas, Mary Patton, Mandel Kramer, Rosemary Murphy, Sidney Paul, Clarke Gordon, Herm Dinken, Jack Grimes, Joseph Bell, Peter Fernandez, Denise Alexander, Joan Alexander, Grant Richards, Charles Carroll, John Moore, Mercer McLeod, Stan Early, Joseph Boland, Ruby Dee, Alan Hewitt, Wililam Quinn, Jan Miner, Alistair Duncan, Ronald Liss, Eleanor Phelps, Pamela Fitzmaurice, James Monks, Lawson Zerbe, Billy Harris, Kate Wilkinson, Sarah Fussell, Teri Keane, Raymond Edward Johnson, Vera Allen, William Redfield, James Stevens, Charles Penman, Craig McDonnell, James Rafferty, Jim Stevens, Wayne Chappell, Hope Risman, Lydia Bruce, Michael Ingram, Robert Dryden, Floyd Mack, Frank Maxwell, Dick Janaver, Helen Gerald, John Marley, Alfred Shirley, Burford Hampden, Patsy O'Shea, Allan Mason, Cliff Carpenter, Joseph Sullivan, Bill Britton, Charlotte Manson, John Radee, Merrill E. Joels, Elliott Reid, Audrey Blum, Mary Patton, Peggy Allenby, Dan Ocko, Larry Haines, Dean Olmquist, Amy Sidell, Elaine Rost, Ken Rafitte, Tom Collins, Rolly Bester, Carl Frank, Alan Bergman, Larry Robinson, Alan Hewitt, Floyd Mack, Sam Grey, Ann Thomas, Agnes Young, Butch Cavell, Peter Lazer, Jim Drummond, Frank Milano, Ian Martin, Jock MacGregor, Nat Polen, Phil Sterling, Dennis Bellabio, Robert Haag, Gerianne Raphael, Harold Huber, John Baragrey, Arthur Hughes, Irv West, Court Benson, Elliott Reid, John Griggs, Sam Raskyn, Ann Thomas, Karen Ford, Leona Powers, Edwin Cooper, Pat Hosley, Hetty Galen, Bert Cowlin, Anthony Campbell, Jackson Beck, Bernard Lenrow, Jared Reed, George Erwin, Peter Fernandez, Alice Yourman, Jane Aymar, Maxine Stewart, House Jameson, Lynn Cook, Lydia Bruce, Harvey Hayes, Walter Black, David Ross, Adele Ronson, Ellen Muir, Illya Bracha, David Kerman, Henry Norrell, Betty Caine, Michael Ingram, Frank Silvera, Ann Loring, Evie Juster, Helen Gerald, and Martin Agronsky.