Nick Carter, Master Detective was a Mutual radio crime drama based on tales of the famed detective from Street & Smith's dime novels and pulp magazines. Nick Carter first came to radio as The Return of Nick Carter, a reference to the character's pulp origins, but the title was soon changed to Nick Carter, Master Detective.

With Lon Clark in the title role, the series began April 11, 1943, on Mutual, continuing in many different timeslots for well over a decade. Between October 1944 and April 1945, it was heard as a 30-minute program on Sunday afternoons at 3pm, sponsored by Acme Paints and Lin-X, with a 15-minute serial airing four or five times a week in 1944 from April to September. In April 1945, the Sunday series moved to 6pm, continuing in that timeslot until June 1946, and it was also heard in 1946 on Tuesday from March to August.

Patsy Bowen, Nick's assistant, was portrayed by Helen Choate until mid-1946 and then Charlotte Manson stepped into the role. Nick and Patsy's friend was reporter Scubby Wilson (John Kane). Nick's contact at the police department was Sgt. Mathison (Ed Latimer). The supporting cast included Raymond Edward Johnson, Bill Johnstone and Bryna Raeburn. Michael Fitzmaurice was the program's announcer. The series ended on September 25, 1955.